Highlights from our publications, conference contributions, methods development, research funding and trainee development. Selected milestones from our research community and collaborations.
A Cancer Research Society operating grant has been approved. Epigenome Lab is a collaborator on this project investigating DDX55 in prostate cancer, contributing expertise in epigenomic profiling and integrative analysis.
A collaborative bioRxiv preprint profiles cancer cell-line chromatin landscapes and describes enhancer-defined subtypes across cancers. This work has not yet been peer reviewed.
Read the preprintOur study in Communications Biology profiles 51,248 cells from nine mouse tissues, mapping conserved and tissue-specific regulatory programs.
Read the studyA systematic comparison of MACS2, SEACR, GoPeaks and LanceOtron provides guidance for method selection and reproducible epigenomics analyses.
Read the paperThe group participated virtually. A published ASCO abstract describes integrative epigenomic analysis for precision therapeutics; it was co-authored by Ghazaleh Tavallaee, Amin Nooranikhojasteh and Elias Orouji.
Meeting abstractAmin Nooranikhojasteh attended the AACR Annual Meeting in person and presented the lab’s 3D genome framework. The related meeting abstract is available in Cancer Research.
Meeting abstractOur review in Computational and Structural Biotechnology Journal surveys methods for measuring and interpreting three-dimensional genome organization.
Read the reviewOur laboratory participated virtually in a Cold Spring Harbor Laboratory scientific meeting in 2023.
CSHL meetingsAn approximately $0.8 million CIHR Project Grant led by Elias Orouji supports research into epigenetic regulation and therapeutic vulnerabilities in metastatic melanoma.
CIHR funding decisionsA CIHR Project Grant of approximately $1.1 million supports research on 3D genome architecture and genetic susceptibility in prostate cancer. Housheng H. He is the listed principal investigator, and Elias Orouji serves as co-principal investigator.
CIHR funding decisionsOur laboratory has hosted University of Waterloo co-op trainees Jakob Zerbs and Hossein Molavi and a visiting student from the Technical University of Munich in Germany. Hossein’s placement received TECHNATION Canada support.
Meet our alumniAn approximately $0.9 million CIHR Project Grant led by Elias Orouji supports research integrating epigenomic profiling and patient-derived cancer models to investigate potential therapeutic strategies.
CIHR funding decisionsEpigenome Lab research is supported by two PI-led CIHR grants (approximately $0.9 million and $0.8 million). Our principal investigator also serves as co-PI on an approximately $1.1 million CIHR-funded project and as a collaborator on a Cancer Research Society (CRS) operating grant.
CIHR funding databaseOur laboratory has hosted co-op students from the University of Waterloo and a remote co-op student from the Technical University of Munich (TUM), Germany. We also received TECHNATION Canada funding to support a University of Waterloo co-op placement.
Team and alumni