FIELD 01
Cancer epigenomics
Chromatin regulation, enhancer activity and epigenomic changes affecting cancer cell identity and progression.
Explore focusCancer epigenomics · computational genomics · translational oncology
Decoding the epigenome to understand cancer.
We combine experimental epigenomics, computational genomics and machine learning to investigate the regulatory mechanisms of cancer progression and therapeutic response. By connecting multiomics data with clinically relevant models, we aim to advance biological discovery and precision oncology.
AT THE INTERSECTION OFGenome biology · Data science · Oncology
Exploring cancer across molecular scales
EpigenomicsMachine learningPrecision oncology
Our research
From genome regulation
to translational insights.
Four integrated research themes spanning experimental, computational and clinically relevant cancer biology.
FIELD 02
Single-cell multiomics
Integrative analysis of cellular heterogeneity, plasticity and cancer-associated regulatory programs.
Explore focus
FIELD 03
3D genome architecture
Chromatin interactions, genome organization and the functional architecture of regulatory DNA.
Explore focus
FIELD 04
Translational oncology
Patient-derived models, molecular stratification and candidate biomarkers or therapeutic vulnerabilities.
Explore focusComputational discovery
Machine learning meets genome biology.
We develop and apply statistical, computational and machine-learning approaches—from deep-learning-assisted 3D genome analysis to unsupervised multiomics modelling—to extract biological meaning from high-dimensional datasets.
3D genomicsStatistical learningSingle-cell integration
Selected publications
Recent work.
Chromatin accessibility landscapes define stromal cell identities across tissues
Amin Nooranikhojasteh, Ghazaleh Tavallaee, Nicholas Khuu, Shu Yi Shen, Shaida Ouladan, Ayush Raman, Elias Orouji
Communications BiologyRead paper
Benchmarking peak calling methods for CUT&RUN
Amin Nooranikhojasteh, Ghazaleh Tavallaee, Elias Orouji
BioinformaticsRead paper
Chimeric Antigen Receptor-T Cells in Colorectal Cancer: Pioneering New Avenues in Solid Tumor Immunotherapy
Shaida Ouladan, Elias Orouji
Journal of Clinical OncologyRead paper
Lab highlights